SUBCELLULAR DRUG TARGETING ILLUMINATES LOCAL KINASE ACTION

Subcellular drug targeting illuminates local kinase action

Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes.A-kinase anchoring proteins (AKAPs) Catchers restrict the range of action of protein kinases within intracellular compartments.We exploited the AKAP targeting concept to create genetically encoded platforms that restrain

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